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A payment that a Federal awarding agency or pass through entity makes by any appropriate payment mechanism, including a predetermined payment schedule, before the non-Federal entity disburses the funds for program purposes.

To learn more about policies and guidance on the use of animals in PHS funded research, training, and testing, see the NIH Office of Laboratory Animal Welfare.

Annual Payback Activities Certifications (APACs) for PHS 6031-1 are notices used by Kirschstein-NRSA recipients to report on their payback activities annually, until their payback obligation is fulfilled.

A request for (or the award of) additional funds during a current project period to provide for an increase in costs due to unforeseen circumstances.

All additional costs must be within the scope of the peer reviewed and approved project.

An IC may request to change this assignment if the application is more suited to another IC. The general business management practices that are common to the administration of all grants, such as financial accountability, reporting, equipment management, and retention of records.

Uniform administrative requirements for grants are found in OMB Circular A-102 and OMB Circular A-110 (now found at 2 CFR Part 215).

An appeal is a written communication from a Program Director/Principal Investigator (PD/PI) and/or applicant institution that meets the following four criteria: 1) is received after issuance of the summary statement and up to 30 calendar days after the second level of peer review, 2) describes a flaw or perceived flaw in the review process for a particular application, 3) is based on one or more of four allowable issues (described below), and 4) displays concurrence from the Authorized Organization Representative (AOR).

Applicable clinical trial is the term used in Title VIII of the Food and Drug Administration Amendments Act (FDAAA) of 2007 (P. 110-85) to designate the scope of clinical trials that may be subject to the registration and results reporting requirements in FDAAA.

The cost of the asset including the cost to ready the asset for its intended use.

Acquisition cost for equipment, for example, means the net invoice price of the equipment, including the cost of any modifications, attachments, accessories, or auxiliary apparatus necessary to make it usable for the purpose for which it is acquired.

The A1 suffix is typically seen as part of an application identification number or grant number and “A1” is often used to refer to a new, renewal, or revision application that is amended and resubmitted after the review of a previous application with the same project number.